Journal of Molecular Signaling Updates

Journal of Molecular Signaling Updates - Volume 1

Cytoskeletal Signaling in Brain Tumors

Published on: 01 January 2016

Pages: 01-10

Quincy A. Quick

Department of Biological Sciences, Tennessee State University, 3500 John A. Merritt Blvd, Nashville, TN 37209, USA

Abstract: The pervasive view of cytoskeleton signaling has been the role of Small RhoGTPases as signaling mediators of cytoskeleton dynamics. However, cytoskeleton signaling has emerged to include cytoskeleton proteins as effector targets and modulators of signal transduction that contribute to numerous cell biological regulatory functions and behaviors. Cytoskeleton proteins, specifically intermediate filaments are used clinically as biomarkers for brain tumors and typically have high expression levels in these cancers. This suggests that the function of actin, microtubules, intermediate filaments and their associated proteins extend beyond that of structural platforms in this disease. Here we expand the functional perspective of cytoskeleton proteins in brain tumors as intracellular signaling regulators, mediators of cell cycle control, and address the diversity of receptor-mediated signaling on cytoskeleton dynamics within and between brain tumor subtypes. Collectively, gaining a better understanding of cytoskeleton signaling mechanisms in cellular and genetically heterogeneous brain tumors will expand our approach to novel therapeutic paradigms for the treatment of this disease.

Keywords: Actin, Microtubules, Intermediate filaments, Signaling, Gliomas.

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