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Journal of Advanced Biomarkers Research

Journal of Advanced Biomarkers Research - Volume 2

Procollagen III Peptide, Fibronectin and Hyaluronic Acid Biomarkers as Non Invasive Diagnostic Tools in Patients with Different Stages of Chronic Hepatitis C

Published on: 06 May 2016

Pages: 1-7

Abousree Taha Ellethy

Department of Oral and Medical Basic Sciences, Biochemistry Division, College of Dentistry, Qassim University, KSA

Abstract: Liver biopsy is still a disturbing method subjected to spectator inconsistency for staging liver fibrosis. The present study was to evaluate of procollagen III peptide, hyaluronic acid, and fibronectin in liver fibrosis as biomarkers for chronic viral hepatitis C patients against the golden standard assays based histological liver features. Whole blood was collected from 38 patients and 16 healthy controls. Procollagen III peptide was measured in serum by radio-immunoassay. Fibronectin and hyaluronic acid were measured in plasma and serum respectively, based sandwich enzyme linked immunosorbent assay. Different grades of hepatic fibrosis, portal, portolobular fibrosis and cirrhosis were investigated as golden standard diagnostic tests. All patients with fibrotic liver had significantly higher levels of both procollagen III peptide and hyaluronic acid than controls. They were higher in the patients with hepatic fibrosis than the remaining non-fibrotic cases. Regarding fibronectin plasma levels, no significant difference was found between normal subjects and patients with grade 0, 1 or 2 fibrosis. Higher positive and negative predictive values for diagnosis of fibrosis and cirrhosis were observed with hyaluronic acid (83% and 82%) alternatively, while lower predictive values were observed with fibronectin (60% and 63%) alternatively. The diagnostic value of serum hyaluronic acid is greater than both serum Procollagen III peptide and plasma fibronectin as a biomarker for different grades of liver fibrosis. It should be preferred as a non-invasive biochemical test for monitoring early fibrotic processes in the course of hepatitis C patients. Fibronectin was detected only in advanced cases (cirrhosis).

Keywords: Procollagen III, Fibronectin, Hyaluronic acid, Hepatitis C, Hepatic fibrosis.

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