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Global Journal of Parasitology

Global Journal of Parasitology - Volume 1

Antimalarial Activities of Seaweeds Spatoglossumschroederi, Gracilariabirdiae and Udotea flabellum from Rio Grande do Norte Coast, Brazil

Published on: 31 December 2015

Pages: 22-28

Gracielle Rodrigues Dantas1, Hugo Alexandre Oliveira Rocha2, Rodrigo César das Neves Amorim3, Luís Francisco Rocha Silva3,4, Adrian Martin Pohlit3and Valter Ferreira de Andrade-Neto1

1Laboratory of Malaria and Toxoplasmosis Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte-UFRN, Lagoa Nova 59078-970 | Natal/RN – Brazil; 2Laboratory of Biochemistry of Polymers, Department of Biochemistry, Federal University of Rio Grande do Norte-UFRN, Lagoa Nova 59078-970 | Natal/RN – Brazil; 3Laboratory of Active Principles, Amazon Research Institute-INPA, Manaus/AM-Brazil and 4Malaria Laboratory, Tropical Medicine Instituteof Amazonas-IMTAM, Manaus/AM-Brazil

Abstract:

Aim: The present study aimed to evaluate the antimalarial activity in vitro and in vivo of algae extracts, Spatoglossumschroederi, Gracilariabirdiae and Udotea flabellum.

Methods: Due to the emergence of resistant strains, the research to development for new antimalarial drugs is needed. It is known that one of the most promising sources for the development of new anti-malarial drugs is natural products. Therefore, tests were performed in vitro with Plasmodium falciparum 3D7 strain, and cell cytotoxicity assay (MTT assay) with BGM cells and macrophages, acute toxicity test in vivo and in vivo tests on murine model of Plasmodium berghei.

Results: The algae extracts showed cytotoxicity only at the highest concentrations tested. It was not observed in vivo toxicity for the amount used. Spatoglossumshroederi and Udotea flabellum algae were active in vivo for the amount 500mg/kg, with reduction of 52.95% and 44.60% on the fifth day and 37.39% and 54.67% on the seventh day respectively.

Conclusion: Data showed that the present bioactive components in these algae can be promising for the development of new antimalarial drugs; attemptsto purifythese compoundsare in progressfor furtherbiological assays.

Keywords: Malaria, Seaweeds, Natural products, Antispasmodial activity.

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